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Our research and publications
Clinical experience gained in different specialisms, and longstanding involvement in research, has resulted in us collaborating on a significant number of peer-reviewed scientific publications, books and book chapters. Many are highly cited. These cover themes including autism assessment, understanding and improving the mental health and emotional wellbeing of autistic children, young people and adults, and adaptations to psychological therapies.
Autism
Books
Spain, D., Musich, F. & White. S. (editors) (2022). Psychological therapies for adults with autism. Oxford University Press.
Chaplin, E., Spain, D. & McCarthy, J. (editors) (2019). Common mental health conditions in adults with autism spectrum disorders: Assessment and intervention. London: Jessica Kingsley Publishers.
Chaplin, E., McCarthy, J., Hardy, S., Underwood, L., Spain, D., Cronin, P., ... & Henry, J. (2014). Guided self-help for people with intellectual disabilities and anxiety and depression. London: Pavilion.
Journal Articles and Book Chapters
Adult Autism Assessment
Ashwood, K., Gillan, N., Horder, J., Hayward, H., Woodhouse, E. L., McEwen, F. S., ... Murphy, D. (2016). Predicting the diagnosis of autism in adults using the Autism-Spectrum Quotient (AQ) questionnaire. Psychological Medicine, 46, 2595-2604.
Wilson, C., Murphy, C., McAlonan, G., Robertson, D., Spain, D., Hayward, H., … Murphy, D. (2016). Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? Autism, 20, 808-19.
https://journals.sagepub.com/doi/10.1177/1362361315611381
Spain, D. & Robertson, D. (2013). Assessment and diagnosis of autism spectrum conditions. In Chaplin, E., Underwood, L. & Hardy, S. (editors). Autism spectrum conditions: A guide. London: Pavilion.
Wilson, E., Gillan, N., Spain, D., Robertson, D., Roberts, G., Murphy, C., … Murphy, D. (2013). Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an adult autism spectrum disorder diagnostic clinic. Journal of Autism & Developmental Disorders, 43, 2515-2525.
https://link.springer.com/article/10.1007/s10803-013-1799-6
Autism and Gender
Lockwood Estrin, G., Milner, V., Spain, D., Happé, F. & Colvert, E. (2021). Barriers to autism spectrum disorder diagnosis in young women and girls: A systematic review. Review Journal of Autism & Developmental Disorders, 8, 454-470.
https://link.springer.com/article/10.1007/s40489-020-00225-8
Blainey, S. and Spain, D. (2014). Cognitive behaviour therapy (CBT)-based groups for women on the autistic spectrum. Network Autism.
Lai, M., Lombardo, M., Ruigrok, A., Chakrabarti, B., Wheelwright, S., Auyeung, B., … Baron-Cohen, S. (2012). Cognition in males and females with autism: Similarities and differences. PLoS ONE, 7, e47198. 302.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047198
Lai, M., Lombardo, M., Pasco, G., Ruigrok, A., Wheelwright, S., Sadek, S., … Baron-Cohen, S. (2011). A behavioural comparison of male and female adults with high functioning autism spectrum conditions. PLoS ONE, 6, e20835.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020835
Understanding the Mental Health of Autistic Adults
Spain, D., Chaplin, E. & McCarthy, J. (2019). Introduction. In Chaplin, E., Spain, D. & McCarthy, J. (editors). Common mental health conditions in adults with autism spectrum disorders: Assessment and intervention. London: Jessica Kingsley Publishers.
Russell, A., Murphy, C., Wilson, E., Gillan, N., Brown, C., Robertson, D., ... Murphy, D. (2016). The mental health of individuals referred for assessment of autism spectrum disorder in adulthood: A clinic report. Autism, 20, 623–627.
https://journals.sagepub.com/doi/10.1177/1362361315604271
Alexithymia
Josyfon, E., Spain, D., Blackmore, C., Murphy, D., & Oakley, B. (2024). Alexithymia in adult autism clinic service-users: Relationships with sensory processing differences and mental health. Healthcare, 11, No. 24, p. 3114.
https://www.mdpi.com/2227-9032/11/24/3114
Sleep and autism
Spain, D. & Galanopoulos, A. https://www.middletownautism.com/social-media/podcast-sleep-with-debbie-spain-and-tasos-galanopoulos-1-2024
Spain, D. & Galanopoulos, A. https://www.autistica.org.uk/what-is-autism/anxiety-and-autism-hub/sleep-and-anxiety.
Social anxiety and autism
Spain, D., Zivrali, E. & Happé, F. (2020). Social anxiety in adults with autism: A qualitative study. International Journal of Qualitative Studies on Health & Well-being, 15, 1803669.
https://www.tandfonline.com/doi/full/10.1080/17482631.2020.1803669
Spain, D. (2019). Social anxiety. In Chaplin, E., Spain, D. & McCarthy, J. (editors). Common mental health conditions in adults with autism spectrum disorders: Assessment and intervention. London: Jessica Kingsley Publishers.
Spain, D. (2018). Social anxiety in adults with autism spectrum disorders. Doctoral thesis. King's College London.
https://kclpure.kcl.ac.uk/ws/portalfiles/portal/104605385/2018_Spain_Debbie_1167247_ethesis.pdf
Spain, D., Sin, J., Linder, K., McMahon, J. & Happé, F. (2018). Social anxiety in autism spectrum disorder: A systematic review. Research in Autism Spectrum Disorders, 52, 51-68.
https://www.sciencedirect.com/science/article/pii/S1750946718300643
Spain, D., Rumball, F., O'Neill, L., Sin, J., Prunty, J. & Happé, F. (2017). Conceptualizing and treating social anxiety in autism spectrum disorder: A focus group study with multidisciplinary professionals. Journal of Applied Research in Intellectual Disabilities, 30, 10-21.
https://onlinelibrary.wiley.com/doi/abs/10.1111/jar.12320
Spain, D*., Happé, F.*., Johnston, P., Campbell, M., Sin, J., Daly, E., … Murphy, D. (2016). Social anxiety in adult males with autism spectrum disorders. Research in Autism Spectrum Disorders, 32, 13-23.
https://www.sciencedirect.com/science/article/pii/S1750946716300927
Post-traumatic stress disorder and autism
Sarr, R., Spain, D., Quinton, A., Happe, F., Brewin, C., Radcliffe, J., … Rumball, F. (2025). Differential diagnosis of autism, attachment disorders, complex post-traumatic stress disorder and emotionally unstable personality disorder: A Delphi survey. British Journal of Psychology, 116, 1-33.
https://bpspsychub.onlinelibrary.wiley.com/doi/10.1111/bjop.12731
Rumball, F., Parker, R., Madigan, A. E., Happe, F. & Spain, D. (2024). Elucidating the presentation and identification of PTSD in autistic adults: A modified Delphi study. Advances in Autism, 10(3), 163-184.
https://www.emerald.com/insight/content/doi/10.1108/aia-08-2023-0053/full/html
Rumball, F. & Spain, D. (2019). Post-traumatic stress disorder. In Chaplin, E., Spain, D. & McCarthy, J. (editors). Common mental health conditions in adults with autism spectrum disorders: Assessment and intervention. London: Jessica Kingsley Publishers.
Obsessive compulsive disorder and autism
Cadman, T*., Spain, D*., Johnston, P., Russell, A., Mataix-Cols, D., Craig, M., … Murphy, D. (2015). Obsessive-compulsive disorder in adults with high-functioning autism spectrum disorder: What does self-report with the OCI-R Tell Us? Autism Research, 8, 477-485.
https://onlinelibrary.wiley.com/doi/10.1002/aur.1461
Personality disorder and autism
Gillett, G., Leeves, L., Patel, A., Prisecaru, A., Spain, D*., & Happé, F*. (2023). The prevalence of autism spectrum disorder traits and diagnosis in adults and young people with personality disorders: A systematic review. Australian & New Zealand Journal of Psychiatry, 57, 181-196.
https://journals.sagepub.com/doi/full/10.1177/00048674221114603
Paranoia and autism
Spain, D., Sin, J. & Freeman, D. (2016). Conceptualising paranoia in ASD: A systematic review and development of a theoretical framework. Research in Autism Spectrum Disorders, 25, 97-111.
https://www.sciencedirect.com/science/article/pii/S1750946716300137
Psychosis and autism
Spain, D., Canning, A., Toogood, H. & Galanopoulos, A. https://www.autistica.org.uk/what-is-autism/psychosis-and-autism. Autistica.
Risk, crisis and autism
Gray, E., Rumball, Happé, F., Quinton, A. & Spain, D. (2025). Why does someone need to have a crisis before anyone will do anything?: Perspectives of Autism Intensive Support Team staff. Research in Autism, 123.
https://www.sciencedirect.com/science/article/pii/S3050656525000173
Allahdad, M., Gluyas, E., Spain, D., Blainey, S., Doswell, S., & Onyejiaka, A. (2024). Implementing ‘Transforming Care’–The first two years of a pilot service for autistic adults experiencing mental health crisis warranting psychiatric admission. Research in Developmental Disabilities, 147, 104700.
https://www.sciencedirect.com/science/article/abs/pii/S0891422224000325?via%3Dihub
Autistica, autism community, Cassidy, S., Rodgers, J., Kyriakopoulos, M., Spain, D. et al. Supporting autistic children and young people through crisis – an Autistica evidence resource on suicide for crisis workers. Autistica.
https://www.autistica.org.uk/downloads/files/Crisis-resource-2020.pdf
Adapting Psychological Therapy for Autistic Children and Young People
Pemovska, T., Loizou, S., Appleton, R., Spain, D., Stefanidou, T., Kular, A., ... & Johnson, S. (2024). Approaches to improving mental health care for autistic children and young people: A systematic review and meta-analysis. Psychological Medicine, 1-31.
Adapting Psychological Therapy for Autistic Adults
White, S., Golt, J., Musich, F. & Spain, D (2024). Psychotherapeutic Approaches for Autistic Adolescents and Adults. Volkmar, F., Reichow, B. & McPartland, J. (editors). Adolescents and adults with autism spectrum disorders. Springer.
https://link.springer.com/chapter/10.1007/978-3-031-46463-8_17
Loizou, S., Pemovska, T., Stefanidou, T., Foye, U., Cooper, R., Kular, A., ... & Johnson, S. (2024). Approaches to improving mental healthcare for autistic people: systematic review. BJPsych Open, 10(4), e128.
Mason, D., Stark, E., Musich, F. & Spain, D. (2022). Psychological therapy as an autistic person. In Spain, D., Musich, F. & White. S. (editors). Psychological therapies for adults with autism. Oxford University Press
https://oxfordjournals.org/book/37230/chapter-abstract/329246202?redirectedFrom=fulltext
Spain, D., Musich, F. & White, S. (2022). Ensuring Accessible and Acceptable Service Delivery for Adults with Autism. In Spain, D., Musich, F. & White. S. (editors). Psychological therapies for adults with autism. Oxford University Press
https://academic.oup.com/book/37230/chapter-abstract/329248434?redirectedFrom=fulltext
Spain, D., O'Neill, L., Harwood, L. & Chaplin, E. (2016). Psychological interventions for adults with ASD: Clinical approaches. Advances in Autism, 2, 24-30.
https://www.emerald.com/insight/content/doi/10.1108/aia-09-2015-0016/full/html
Spain, D., Harwood, L. & O'Neill, L. (2015). Psychological interventions for adults with autism spectrum disorders: A review. Advances in Autism, 1, 79-86.
https://www.emerald.com/insight/content/doi/10.1108/aia-05-2015-0007/full/html
Cognitive behaviour therapy (CBT) with autistic people
Spain, D., Milner, V., Mason, D., Iannelli, H., Attoe, C., Ampegama, R., ... & Marshall-Tate, K. (2023). Improving cognitive behaviour therapy for autistic individuals: A Delphi survey with practitioners. Journal of Rational-Emotive & Cognitive-Behavior Therapy, 41, 45-63.
https://link.springer.com/article/10.1007/s10942-022-00452-4
Spain, D. & Happé, F. (2020). How to Optimise Cognitive Behaviour Therapy (CBT) for People with Autism Spectrum Disorders (ASD): A Delphi Study. Journal of Rational-Emotive & Cognitive-Behavior Therapy, 38, 184–208.
https://link.springer.com/article/10.1007/s10942-019-00335-1
Spain, D. (2019). Cognitive behaviour therapy. In Chaplin, E., Spain, D. & McCarthy, J. (editors). Common mental health conditions in adults with autism spectrum disorders: Assessment and intervention. London: Jessica Kingsley Publishers.
Spain, D. & Blainey, S. (2017). Enhancing self-esteem in adults with autism spectrum disorders: A pilot cognitive behaviour therapy (CBT) group intervention. Advances in Autism, 3, 66-75.
https://www.emerald.com/insight/content/doi/10.1108/aia-06-2016-0018/full/html
Spain, D., Blainey, S. & Vaillancourt, K. (2017). Group cognitive behaviour therapy (CBT) for social interaction anxiety in adults with autism spectrum disorders (ASD). Research in Autism Spectrum Disorders, 41, 20-30.
https://www.sciencedirect.com/science/article/pii/S1750946717300855?via%3Dihub
Spain, D., Sin, J., Harwood, L., Mendez, A. & Happé, F. (2017). Cognitive behaviour therapy for social anxiety in autism spectrum disorder: A systematic review. Advances in Autism, 3, 34-46.
https://www.emerald.com/insight/content/doi/10.1108/aia-07-2016-0020/full/html
Spain, D., Sin, J., Chalder, T., Murphy, D. & Happé, F. (2015). Cognitive behaviour therapy for adults with autism spectrum disorders and psychiatric co-morbidity: A review. Research in Autism Spectrum Disorders, 9, 151-162.
https://www.sciencedirect.com/science/article/pii/S1750946714002608
Eye movement desensitisation and reprocessing therapy (EMDR) with autistic people
van Diest, C., Leoni, M., Fisher, N., & Spain, D. (2022). Using EMDR With Autistic Clients: How Do Therapists Adapt?. Journal of EMDR Practice & Research, 16, 123-134.
https://spj.science.org/doi/10.1891/EMDR-2022-0014
Fisher, N., Patel, H., van Diest, C., & Spain, D. (2022). Using eye movement desensitisation and reprocessing (EMDR) with autistic individuals: A qualitative interview study with EMDR therapists. Psychology and Psychotherapy: Theory, Research and Practice, 95, 1071-1089.
https://bpspsychub.onlinelibrary.wiley.com/doi/10.1111/papt.12419
Fisher, N., van Diest, C., Leoni, M. & Spain, D. (2022). Using Eye Movement Desensitisation and Reprocessing (EMDR) with autistic individuals: A Delphi survey with EMDR therapists. Autism, 27, 43-53.
https://journals.sagepub.com/doi/10.1177/13623613221080254
Compassion-focused therapy with autistic people
Mason, D., Acland, J., Stark, E., Happé, F., & Spain, D. (2023). Compassion-focused therapy with autistic adults. Frontiers in Psychology, 14, 1267968.
https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2023.1267968/full
Acland, J. & Spain, D. (2022). Compassion-focused therapy. In Spain, D., Musich, F. & White. S. (editors). Psychological therapies for adults with autism. Oxford University Press
https://academic.oup.com/book/37230/chapter-abstract/329247814?redirectedFrom=fulltext
Systemic (family) therapy with autistic people and their families
Spain, D., Sin, J., Paliokosta, E., Furuta, M., Prunty, J., Chalder, T., ... & Happé, F. (2017). Family therapy for autism spectrum disorders: Review. The Cochrane Library.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011894.pub2/full
Spain, D., Sin, J., Paliokosta, E., Furuta, M., Prunty, J., Chalder, T., ... & Happé, F. (2016). Family therapy for autism spectrum disorders: Protocol. The Cochrane Library.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011894.pub2/full
Social skills interventions with autistic people
Spain, D. & Blainey, S. (2015). Group social skills interventions for adults with high-functioning autism spectrum disorders: A systematic review. Autism, 19, 874-886.
https://journals.sagepub.com/doi/10.1177/1362361315587659
The impact of the COVID-19 pandemic on autistic people, their families and autism services
Evers, K., Gijbels, E., Maljaars, J., Rumball, F., Spain, D., Happé, F., & Noens, I. (2023). Mental health of autistic adults during the COVID-19 pandemic: The impact of perceived stress, intolerance of uncertainty, and coping style. Autism, 27, 832-847.
https://journals.sagepub.com/doi/10.1177/13623613221119749
Spain, D., Stewart, G. R., Mason, D., Robinson, J., Capp, S., Gillan, N., ... & Happé, F. (2022). Autism diagnostic assessments with children, adolescents, and adults prior to and during the COVID-19 pandemic: a cross-sectional survey of professionals. Frontiers in Psychiatry, 13, 789449.
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.789449/full
Spain, D., Stewart, G., Mason, D., Milner, V., Fairhurst, B., Robinson, J., ... & Happe, F. (2022). Telehealth autism diagnostic assessments with children, young people, and adults: Qualitative interview study with England-wide multidisciplinary health professionals. JMIR Mental Health, 9, e37901.
https://mental.jmir.org/2022/7/e37901
Maljaars, J., Gifjbels, E., Evers, K., Spain, D., Rumball, F., Happé, F. & Noens, I. (2022). Impact of the COVID-19 pandemic on daily life: diverse experiences for autistic adults. Journal of Autism & Developmental Disorders, 53, 319-331.
https://link.springer.com/article/10.1007/s10803-022-05437-x
White, S., Stoppelbein, L., Scott, H., & Spain, D. (2021). It took a pandemic: Perspectives on impact, stress, and telehealth from caregivers of people with autism. Research in Developmental Disabilities, 113, 103938.
https://www.sciencedirect.com/science/article/pii/S0891422221000871?via%3Dihub
Spain, D., Mason, D., Capp, S., Stoppelbein, L., White, S., & Happé, F. (2021). “This may be a really good opportunity to make the world a more autism friendly place”: Professionals’ perspectives on the effects of COVID-19 on autistic individuals. Research in Autism Spectrum Disorders, 83, 101747.
https://www.sciencedirect.com/science/article/pii/S1750946721000222?via%3Dihub
Autism and Neuropsychology
Johnston, K., Murray, K., Spain, D., Walker, I. & Russell, A. (2019). Executive function: cognition and behaviour in adults with autism spectrum disorders (ASD). Journal of Autism & Developmental Disorders, 49, 4181-4192.
https://link.springer.com/article/10.1007/s10803-019-04133-7
Murray, K., Johnston, K., Cunnane, H., Kerr, C., Spain, D., Gillan, N., ... & Happé, F. (2017). A new test of advanced theory of mind: The “Strange Stories Film Task” captures social processing differences in adults with autism spectrum disorders. Autism Research, 10, 1120-1132.
https://onlinelibrary.wiley.com/doi/10.1002/aur.1744
Wilson, C., Happé, F., Wheelwright, S. J., Ecker, C., Lombardo, M., Johnston, P., ... Murphy, D. (2014). The neuropsychology of male adults with high-functioning autism or Asperger syndrome. Autism Research, 7, 568-581.
https://onlinelibrary.wiley.com/doi/10.1002/aur.1394
Autism and Camouflaging
Lai, M., Lombardo, M., Chakrabarti, B., Ruigrok, A., Bullmore, E., Suckling, J., ... & MRC AIMS Consortium (2019). Neural self-representation in autistic women and association with ‘compensatory camouflaging’. Autism, 23, 1210-1223.
https://journals.sagepub.com/doi/10.1177/1362361318807159
Lai, M., Lombardo, M., Ruigrok, A., Chakrabarti, B., Auyeung, B., Szatmari, P., … MRC AIMS Consortium, (2016). Quantifying and exploring camouflaging in men and women with autism. Autism, 21, 690-702.
https://journals.sagepub.com/doi/10.1177/1362361316671012
Autism and Ageing
Yarar, E., Roestorf, A., Spain, D., Howlin, P., Bowler, D., Charlton, R., & Happé, F. (2022). Aging and autism: Do measures of autism symptoms, co‐occurring mental health conditions, or quality of life differ between younger and older autistic adults?. Autism Research, 15, 1482-1494.
https://onlinelibrary.wiley.com/doi/10.1002/aur.2780
Autism and the Criminal Justice System
Blackmore, C., Woodhouse, E., Gillan, N., Wilson, E., Ashwood, K., Stoencheva, V., ... & Daly, E. (2022). Adults with autism spectrum disorder and the criminal justice system: An investigation of prevalence of contact with the criminal justice system, risk factors and sex differences in a specialist assessment service. Autism, 26, 2098-2107.
https://journals.sagepub.com/doi/full/10.1177/13623613221081343
Autism and Imaging
Olafson, E., Bedford, S., Devenyi, G., Patel, R., Tullo, S., Park, M., ... & Chakravarty, M. (2021). Examining the Boundary Sharpness Coefficient as an Index of Cortical Microstructure in Autism Spectrum Disorder. Cerebral Cortex, 31, 3338-3352.
https://academic.oup.com/cercor/article/31/7/3338/6162915
Mann, C., Schäfer, T., Bletsch, A., Gudbrandsen, M., Daly, E., Suckling, J., ... & Ecker, C. (2021). Examining volumetric gradients based on the frustum surface ratio in the brain in autism spectrum disorder. Human Brain Mapping, 42, 953-966.
https://onlinelibrary.wiley.com/doi/10.1002/hbm.25270
Bletsch, A., Schafer, T., Mann, C., Andrews, D., Daly, E., Gudbrandsen, M., … & Ecker, C. (2020). Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood. Human Brain Mapping, 42, 467-484.
https://onlinelibrary.wiley.com/doi/10.1002/hbm.25237
Trakoshis, S., Martinez-Canada, P., Rocchi, F., Canella, C., You, W., Chakrabarti, B., ... & Lombardo, M. (2020). V. Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women. eLife.
https://elifesciences.org/articles/55684
Bedford, S., Park, M., Devenyi, G., Tullo, S., Germann, J., Patel, R., ... & Chakravarty, M. (2020). Large-scale analyses of the relationship between sex, age and intelligence quotient heterogeneity and cortical morphometry in autism spectrum disorder. Molecular Psychiatry, 25, 614-628.
https://www.nature.com/articles/s41380-019-0420-6
Górriz, J., Ramirez, J., MRC AIMS Consortium & Suckling, J. (2019). On the computation of distribution-free performance bounds: Application to small sample sizes in neuroimaging. Pattern Recognition, 93, 1-13.
https://www.sciencedirect.com/science/article/abs/pii/S0031320319301402
Guo, X., Simas, T., Lai, M., Lombardo, M., Chakrabarti, B., Ruigrok, A., ... & MRC AIMS Consortium. (2019). Enhancement of indirect functional connections with shortest path length in the adult autistic brain. Human Brain Mapping, 40, 5354-5369.
https://onlinelibrary.wiley.com/doi/10.1002/hbm.24777
Horder, J., Andersson, M., Mendez Hernandez, A., Singh, N., Tangen, A., Lundberg, J., ... Borg, J. (2018). GABA receptor availability is not altered in adults with autism spectrum disorder or in mouse models. Science Translational Medicine, 10, eaam8434.
https://www.science.org/doi/10.1126/scitranslmed.aam8434
Mann, C., Bletsch, A. Andrews, D., Daly, E., Murphy, C., MRC AIMS Consortium ... &. Ecker, C. (2018). The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder. Molecular Autism, 9, 49.
https://molecularautism.biomedcentral.com/articles/10.1186/s13229-018-0232-6
Andrews, D., Avino, T., Gudbrandsen, M., Daly, E., Marquand, A., Murphy, C., … Ecker, C. (2017). In vivo evidence of reduced integrity of the gray-white matter boundary in autism spectrum disorder. Cerebral Cortex, 27, 877–887.
https://academic.oup.com/cercor/article/27/2/877/2834408#
Ecker, C., Andrews, D., Gudbrandsen, C., Marquand, A., Ginestet, C., Daly, E., … MRC AIMS Consortium. (2017). Association between the probability of autism spectrum disorder and the normative sex-related phenotypic diversity in brain structure. JAMA Psychiatry, 74, 329-338.
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2601066
Martinez-Murcia, F., Lai, M., Górriz, J., Ramírez, J., Young, A., Deoni, S., ... Williams, S. (2017). On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis. Human Brain Mapping, 38, 1208-1223.
https://onlinelibrary.wiley.com/doi/10.1002/hbm.23449
Murphy, C., Christakou, A., Giampietro, V., Brammer, M., Daly, E. M., Ecker, C., ... Rubia, K. (2017). Abnormal functional activation and maturation of ventromedial prefrontal cortex and cerebellum during temporal discounting in autism spectrum disorder. Human Brain Mapping, 38, 5343-5355.
https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.23718
Zeestraten, E., Gudbrandsen, M., Daly, E., de Schotten, M., Catani, M., Dell'Acqua, F., ... Murphy, D. M. (2017). Sex differences in frontal lobe connectivity in adults with autism spectrum conditions. Translational Psychiatry, 7, e1090.
https://www.nature.com/articles/tp20179
Durieux, A., Horder, J., Hernandez, A., Egerton, A., Williams, S., Wilson, C., ... McAlonan, G. (2016). Cortical and subcortical glutathione levels in adults with autism spectrum disorder. Autism Research, 9, 429-435.
https://onlinelibrary.wiley.com/doi/full/10.1002/aur.1522
Tropeano, M., Howley, D., Gazzellone, M., Wilson, C., Ahn, J., Stavropoulos, D., ... Murphy, D. (2016). Microduplications at the pseudoautosomal SHOX locus in autism spectrum disorders and related neurodevelopmental conditions. Journal of Medical Genetics, 53, 536-547.
https://jmg.bmj.com/content/53/8/536
Catani, M., Dell'Acqua, F., Budisavljevic, S., Howells, H., Thiebaut De Schotten, M., Froudist-Walsh, S., ... Williams, S. (2016). Frontal networks in adults with autism spectrum disorder. Brain, 139, 616-630.
https://academic.oup.com/brain/article/139/2/616/1753965
Ecker, C., Andrews, D., Dell’Acqua, F., Daly, E., Murphy, C., Catani, M., …MRC AIMS Consortium (2016). Relationship between cortical gyrification, white matter connectivity, and autism spectrum disorder. Cerebral Cortex, 26, 3297-3309.
https://academic.oup.com/cercor/article/26/7/3297/1746394
Lombardo, M., Lai, M., Auyeung, B., Holt, R., Allison, C., Smith, P., … Baron-Cohen, S. (2016). Unsupervised data-driven stratification of mentalizing heterogeneity in autism. Scientific Reports, 6, 35333.
https://www.nature.com/articles/srep35333
Balardin, J., Sato, J., Vieira, G., Feng, Y., Daly, E., Murphy, C., ... MRC AIMS Consortium (2015). Relationship between surface-based brain morphometric measures and intelligence in autism spectrum disorders: Influence of history of language delay. Autism Research, 8, 556-566.
Balardin, J., Comfort, W., Daly, E., Murphy, C., Andrews, D., Murphy, D., … Sato, J. (2015). Decreased centrality of cortical volume covariance networks in autism spectrum disorders. Journal of Psychiatric Research, 69, 142-149.
https://www.sciencedirect.com/science/article/abs/pii/S0022395615002368
Lai, M., Lombardo, M., Ecker, C., Chakrabarti, B., Suckling, J., Bullmore, E., … Baron-Cohen, S. (2015). Neuroanatomy of individual differences in language in adult males with autism. Cerebral Cortex, 25, 3613-3628.
https://academic.oup.com/cercor/article/25/10/3613/389048?login=false
Larson, F., Lai, M., Wagner, A., MRC AIMS Consortium, Baron-Cohen, S., & Holland, A., (2015). Testing the ‘Extreme Female Brain’ theory of psychosis in adults with autism spectrum disorder with or without co-morbid psychosis. PLoS ONE, 10: e0128102.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128102
Deoni, S., Zinkstok, J. R., Daly, E., Ecker, C., Williams, S. C. R., Murphy, D., Bailey, A., ... Williams, S. (2015). White-matter relaxation time and myelin water fraction differences in young adults with autism. Psychological Medicine, 45, 795-805.
Daly, E., Ecker, C., Hallahan, B., Deeley, Q., Craig, M., Murphy, C., ... Murphy, D. (2014). Serotonin, the neural processing of response inhibition and restricted, stereotyped and repetitive behaviours in autism: A functional Magnetic Resonance Imaging study using acute tryptophan depletion. Brain, 137, 2600-2610.
https://academic.oup.com/brain/article/137/9/2600/2848190?login=false
Chantiluke, K., Christakou, A., Murphy, C., Giampietro, V., Daly, E., Ecker, C., Brammer, M., … Rubia, K. (2014). Disorder-specific functional abnormalities during temporal discounting in youth with Attention Deficit Hyperactivity Disorder (ADHD), autism and comorbid ADHD and autism. Psychiatry Research: Neuroimaging, 223, 113-120.
https://www.sciencedirect.com/science/article/pii/S0925492714000936
Murphy, C., Christakou, A., Daly, E., Ecker, C., Giampietro, V., Brammer, M., … MRC AIMS Consortium (2014). Abnormal functional activation and maturation of fronto-striato-temporal and cerebellar regions during sustained attention in autism spectrum disorder. American Journal of Psychiatry, 171, 1107-1116.
https://psychiatryonline.org/doi/full/10.1176/appi.ajp.2014.12030352
Suckling, J., Henty, J., Ecker, C., Deoni, S., Lombardo, M., Baron-Cohen, S., … MRC AIMS Consortium (2014). Are power calculations useful? A multicentre neuroimaging study. Human Brain Mapping, 35, 3569-3577.
https://onlinelibrary.wiley.com/doi/10.1002/hbm.22465
Christakou, A., Murphy, C., Chantiluke, K., Cubillo, A., Smith, A., Giampietro, V., … Rubia, K. (2013). Disorder-specific functional abnormalities during sustained attention in youth with Attention Deficit Hyperactivity Disorder (ADHD) and with autism. Molecular Psychiatry, 18, 236-244.
https://www.nature.com/articles/mp2011185
Ecker, C., Ginestet, C., Feng, Y., Johnston, P., Lombardo, M., Lai, M., … MRC AIMS Consortium (2013). Brain surface anatomy in adults with autism: the relationship between surface area, cortical thickness and autistic symptoms. JAMA Psychiatry, 70, 59-70.
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/1393585
Ecker, C., Ronan, L., Feng, Y., Daly, E., Murphy, C., Ginestet, C., … Murphy, D. (2013). Intrinsic gray-matter connectivity of the brain in adults with autism spectrum disorder. Proceedings of the National Academy of Sciences, 110, 13222–13227.
https://www.pnas.org/doi/full/10.1073/pnas.1221880110
Lai, M., Lombardo, M., Suckling, J., Ruigrok, A., Chakrabarti, B., Ecker, C., … Baron-Cohen, S. (2013). Biological sex affects the neurobiology of autism. Brain, 136, 2799-2815.
https://academic.oup.com/brain/article/136/9/2799/292799?login=false
Sato, J., Hoexter, M., Oliveira Jr, P., Brammer, M., MRC AIMS Consortium, Murphy, D. & Ecker, C. (2013). Inter-regional cortical thickness correlations are associated with autistic symptoms: A machine-learning approach. Journal of Psychiatric Research, 47, 453-459.
https://www.sciencedirect.com/science/article/abs/pii/S0022395612003597
Ecker, C., Suckling, J., Deoni, S., Lombardo, M.V., Bullmore, E., Baron-Cohen, S., … the MRC AIMS Consortium (2012). Brain anatomy and its relationship to behavior in adults with autism spectrum disorder: a multicenter magnetic resonance imaging study. Archives of General Psychiatry, 69, 195-209.
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/1107445
Lai, M., Lombardo, M., Chakrabarti, B., Ecker, C., Sadek, S., Wheelwright, S., … Baron-Cohen, S. (2012). Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults. Neuroimage, 61, 1347-1354.
https://www.sciencedirect.com/science/article/pii/S1053811912002911
Langen, M., Leemans, A., Johnston, P., Ecker, C., Daly, E., Murphy, C., … Murphy, D. (2012). Fronto-striatal circuitry and inhibitory control in autism: Findings from diffusion tensor imaging tractography. Cortex, 48, 183-193.
https://www.sciencedirect.com/science/article/abs/pii/S0010945211001626
Lombardo, M., Chakrabarti, B., Lai, M., MRC AIMS Consortium & Baron-Cohen, S. (2012). Self-referential and social cognition in a case of autism and agenesis of the corpus callosum. Molecular Autism, 3, 14.
https://molecularautism.biomedcentral.com/articles/10.1186/2040-2392-3-14
Lombardo, M., Chakrabarti, B., Bullmore, E., MRC AIMS Consortium & Baron-Cohen, S. (2011). Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism. Neuroimage, 56, 1832-1838.
https://www.sciencedirect.com/science/article/abs/pii/S1053811911002230?via%3Dihub
Ecker, C., Rocha-Rego, V., Johnston, P., Mourao-Miranda, J., Marquand, A., Daly, E., … MRC AIMS Consortium (2010). Investigating the predictive value of whole-brain structural MR scans in autism: A pattern classification approach. Neuroimage, 49, 44-56.
https://www.sciencedirect.com/science/article/abs/pii/S1053811909009045?via%3Dihub
Lai, M., Lombardo, M., Chakrabarti, B., Sadek, S., Pasco, G., Wheelwright, S., … Suckling, J. (2010). A shift to randomness of brain oscillations in people with autism. Biological Psychiatry, 68, 1092-1099.
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(10)00708-0/abstract
Lombardo, M., Chakrabarti, B., Bullmore, E., Sadek, S., Pasco, G., Wheelwright, S., … Baron-Cohen, S. (2010). Atypical neural self-representation in autism. Brain, 133, 611-624.
https://academic.oup.com/brain/article-abstract/133/2/611/287808?redirectedFrom=fulltext
Lombardo, M., Chakrabarti, B., Bullmore, E., Wheelwright, S., Sadek, S., Suckling, J., … Baron-Cohen, S. (2010). Shared neural circuits for mentalizing about the self and others. Journal of Cognitive Neuroscience, 277, 1623-1635.
https://direct.mit.edu/jocn/article/22/7/1623/4904/Shared-Neural-Circuits-for-Mentalizing-about-the
Adult ADHD
Maltezos, S., Horder, J., Coghlan, S., Skirrow, C., O'Gorman, R., Lavender, T., ... Murphy, D. (2014). Glutamate/glutamine and neuronal integrity in adults with ADHD: A proton MRS study. Translational Psychiatry, 4, e373.
https://www.nature.com/articles/tp201411
Bramham, J., Young, S., Bickerdike, A., Spain, D., McCartan, D. & Xenitidis, K. (2009). Evaluation of group cognitive behavioral therapy for adults with ADHD. Journal of Attention Disorders, 12, 434-441.
Alexithymia
Fairhurst, B. (2017). Can’t talk about it, won’t talk about it : how do alexithymia and experiential avoidance relate to men’s experience of psychological distress? Doctoral thesis. University of Surrey.
Post-Traumatic Stress Disorder
Sarr, R., Quinton, A., Spain, D., & Rumball, F. (2024). A Systematic Review of the Assessment of ICD‐11 Complex Post‐Traumatic Stress Disorder (CPTSD) in Young People and Adults. Clinical Psychology & Psychotherapy, 31(3), e3012.
Perinatal Mental Health
Furuta, M., Horsch, A., Ng, E., Bick, D., Spain, D. & Sin, J. (2018). Psychological therapies for treating post-traumatic stress disorder symptoms in women following childbirth: A systematic review and meta-analysis. Frontiers in Psychiatry, 5,591.
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2018.00591/full
Furuta, M., Spain, D., Bick, D., Ng, E. S. W. & Sin, J. (2016). Effectiveness of trauma-focused psychological therapies compared to usual postnatal care for treating post-traumatic stress symptoms in women following traumatic birth: A systematic review protocol. BMJ Open, 6, e013697.
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2018.00591/full
Psychosis
Psychological therapy for Post-traumatic stress disorder in people who have psychosis
Sin, J., Spain, D., Murrells, T., Norman, I. & Furuta, M. (2017). Psychological interventions for post-traumatic stress disorder (PTSD) in people with severe mental illness: Review. The Cochrane Library.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011464.pub2/full
Sin, J. & Spain, D. (2017). Psychological interventions for trauma in individuals who have psychosis: A systematic review and meta-analysis. Psychosis, 9, 67-81.
https://www.tandfonline.com/doi/full/10.1080/17522439.2016.1167946
Sin, J., Spain, D., Murrells, T, Norman, I. & Furuta, M. (2015). Psychological interventions for post-traumatic stress disorder (PTSD) in people with severe mental illness: Protocol. The Cochrane Library.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011464.pub2/full
Understanding the mental health of families of people who have psychosis
Sin, J., Murrells, T., Spain, D., Norman, I. & Henderson, C. (2016). Wellbeing, mental health knowledge and caregiving experiences of siblings of people with psychosis, compared to their peers and parents: An exploratory study. Social Psychiatry & Psychiatric Epidemiology, 51, 1247-1255.
https://link.springer.com/article/10.1007/s00127-016-1222-7
Sin, J., Spain, D., Jordan, C. & Griffiths, C. (2014). Siblings of individuals with severe mental illness. Journal of Mental Health Training, Education & Practice, 9, 215-221.
https://www.emerald.com/insight/content/doi/10.1108/jmhtep-04-2014-0006/full/html
Psychological interventions and therapy for families of people who have psychosis
Sin, J., Henderson, C., Spain, D., Cornelius, V., Chen, T. & Gillard, S. (2018). eHealth interventions for family carers of people with long term illness: A promising approach? Clinical Psychology Review, 60, 109-125.
https://www.sciencedirect.com/science/article/pii/S0272735817300818?via%3Dihub
Sin, J., Henderson, C., Spain, D., Gamble, C. & Norman, I. (2017). What factors influence successful recruitment of siblings of individuals with first episode psychosis to e‐health interventions? A qualitative study. Health Expectations, 20, 696-704.
https://onlinelibrary.wiley.com/doi/10.1111/hex.12508
Sin, J., Gillard, S., Spain, D., Cornelius, V., Chen, T. & Henderson, C. (2017). Effectiveness of psychoeducational interventions for family carers of people with psychosis: A systematic review and meta-analysis. Clinical Psychology Review, 56, 13-24.
https://www.sciencedirect.com/science/article/pii/S0272735816303452
Testimonials
You have both been incredibly kind and nothing has ever seemed too much trouble. The information, guidance and signposting to more sources of support will be invaluable.
It was a real pleasure to talk to people who really understood the complexity and subtlety of my son’s autism...it was great to see how you got beneath the surface to get the real story from him. You were kind, empathetic, encouraging and generous.
Very pleased that we were able to take advantage of their skills to assist [our son] in getting the diagnosis and help that he needs.
This was the best interaction I’ve ever had with professionals, they were super supportive and consistently made sure I was comfortable, and really took the time to understand me and my needs.
Kindness, Compassion, Non-judgemental, Ethical, Collaborative