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Our research and publications

Clinical experience gained in different specialisms, and longstanding involvement in research, has resulted in us collaborating on a significant number of peer-reviewed scientific publications, books and book chapters. Many are highly cited. These cover themes including autism assessment, understanding and improving the mental health and emotional wellbeing of autistic children, young people and adults, and adaptations to psychological therapies. 

Autism

Books

Spain, D., Musich, F. & White. S. (editors) (2022). Psychological therapies for adults with autism. Oxford University Press.

https://global.oup.com/academic/product/psychological-therapies-for-adults-with-autism-9780197548462?cc=gb&lang=en& 

 

Chaplin, E., Spain, D. & McCarthy, J. (editors) (2019). Common mental health conditions in adults with autism spectrum disorders: Assessment and intervention. London: Jessica Kingsley Publishers.

https://us.jkp.com/products/a-clinicians-guide-to-mental-health-conditions-in-adults-with-autism-spectrum-disorders 

 

Chaplin, E., McCarthy, J., Hardy, S., Underwood, L., Spain, D., Cronin, P., ... & Henry, J. (2014). Guided self-help for people with intellectual disabilities and anxiety and depression. London: Pavilion.

https://pavpub.com/learning-disability/ld-mental-health/guided-self-help?srsltid=AfmBOoqAC1Jg1QFHMkvKtLk5Fdmot48v-tk-yQmGySboItzIL1mpjeL4 

Journal Articles and Book Chapters

Adult Autism Assessment 

 

Ashwood, K., Gillan, N., Horder, J., Hayward, H., Woodhouse, E. L., McEwen, F. S., ... Murphy, D. (2016). Predicting the diagnosis of autism in adults using the Autism-Spectrum Quotient (AQ) questionnaire. Psychological Medicine, 46, 2595-2604.

https://www.cambridge.org/core/journals/psychological-medicine/article/predicting-the-diagnosis-of-autism-in-adults-using-the-autismspectrum-quotient-aq-questionnaire/CA0A8294A3494C7F60C166025914294C 

 

Wilson, C., Murphy, C., McAlonan, G., Robertson, D., Spain, D., Hayward, H., … Murphy, D. (2016). Does sex influence the diagnostic evaluation of autism spectrum disorder in adults? Autism, 20, 808-19.

https://journals.sagepub.com/doi/10.1177/1362361315611381 

 

Spain, D. & Robertson, D. (2013). Assessment and diagnosis of autism spectrum conditions. In Chaplin, E., Underwood, L. & Hardy, S. (editors). Autism spectrum conditions: A guide. London: Pavilion. 

https://us.jkp.com/products/a-clinicians-guide-to-mental-health-conditions-in-adults-with-autism-spectrum-disorders  

 

Wilson, E., Gillan, N., Spain, D., Robertson, D., Roberts, G., Murphy, C., … Murphy, D. (2013). Comparison of ICD-10R, DSM-IV-TR and DSM-5 in an adult autism spectrum disorder diagnostic clinic. Journal of Autism & Developmental Disorders, 43, 2515-2525.

https://link.springer.com/article/10.1007/s10803-013-1799-6 


 

Autism and Gender 

 

Lockwood Estrin, G., Milner, V., Spain, D., Happé, F. & Colvert, E. (2021). Barriers to autism spectrum disorder diagnosis in young women and girls: A systematic review. Review Journal of Autism & Developmental Disorders, 8, 454-470.

https://link.springer.com/article/10.1007/s40489-020-00225-8 

 

Blainey, S. and Spain, D. (2014). Cognitive behaviour therapy (CBT)-based groups for women on the autistic spectrum. Network Autism.

 

Lai, M., Lombardo, M., Ruigrok, A., Chakrabarti, B., Wheelwright, S., Auyeung, B., … Baron-Cohen, S. (2012). Cognition in males and females with autism: Similarities and differences. PLoS ONE, 7, e47198. 302.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047198 

 

Lai, M., Lombardo, M., Pasco, G., Ruigrok, A., Wheelwright, S., Sadek, S., … Baron-Cohen, S. (2011). A behavioural comparison of male and female adults with high functioning autism spectrum conditions. PLoS ONE, 6, e20835.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020835 


 

Understanding the Mental Health of Autistic Adults 

 

Spain, D., Chaplin, E. & McCarthy, J. (2019). Introduction. In Chaplin, E., Spain, D. & McCarthy, J. (editors). Common mental health conditions in adults with autism spectrum disorders: Assessment and intervention. London: Jessica Kingsley Publishers.

https://us.jkp.com/products/a-clinicians-guide-to-mental-health-conditions-in-adults-with-autism-spectrum-disorders 

 

Russell, A., Murphy, C., Wilson, E., Gillan, N., Brown, C., Robertson, D., ... Murphy, D. (2016). The mental health of individuals referred for assessment of autism spectrum disorder in adulthood: A clinic report. Autism, 20, 623–627.

https://journals.sagepub.com/doi/10.1177/1362361315604271 


 

Alexithymia 

 

Josyfon, E., Spain, D., Blackmore, C., Murphy, D., & Oakley, B. (2024). Alexithymia in adult autism clinic service-users: Relationships with sensory processing differences and mental health. Healthcare, 11, No. 24, p. 3114.

https://www.mdpi.com/2227-9032/11/24/3114 


 

Sleep and autism 

 

Spain, D. & Galanopoulos, A. https://www.middletownautism.com/social-media/podcast-sleep-with-debbie-spain-and-tasos-galanopoulos-1-2024 

 

Spain, D. & Galanopoulos, A. https://www.autistica.org.uk/what-is-autism/anxiety-and-autism-hub/sleep-and-anxiety


 

Social anxiety and autism

 

Spain, D., Zivrali, E. & Happé, F. (2020). Social anxiety in adults with autism: A qualitative study. International Journal of Qualitative Studies on Health & Well-being, 15, 1803669.

https://www.tandfonline.com/doi/full/10.1080/17482631.2020.1803669 

 

Spain, D. (2019). Social anxiety. In Chaplin, E., Spain, D. & McCarthy, J. (editors). Common mental health conditions in adults with autism spectrum disorders: Assessment and intervention. London: Jessica Kingsley Publishers.

https://us.jkp.com/products/a-clinicians-guide-to-mental-health-conditions-in-adults-with-autism-spectrum-disorders  

 

Spain, D. (2018). Social anxiety in adults with autism spectrum disorders. Doctoral thesis. King's College London. 

https://kclpure.kcl.ac.uk/ws/portalfiles/portal/104605385/2018_Spain_Debbie_1167247_ethesis.pdf 

 

Spain, D., Sin, J., Linder, K., McMahon, J. & Happé, F. (2018). Social anxiety in autism spectrum disorder: A systematic review. Research in Autism Spectrum Disorders, 52, 51-68.

https://www.sciencedirect.com/science/article/pii/S1750946718300643 

 

Spain, D., Rumball, F., O'Neill, L., Sin, J., Prunty, J. & Happé, F. (2017). Conceptualizing and treating social anxiety in autism spectrum disorder: A focus group study with multidisciplinary professionals. Journal of Applied Research in Intellectual Disabilities, 30, 10-21.

https://onlinelibrary.wiley.com/doi/abs/10.1111/jar.12320 

 

Spain, D*., Happé, F.*., Johnston, P., Campbell, M., Sin, J., Daly, E., … Murphy, D. (2016). Social anxiety in adult males with autism spectrum disorders. Research in Autism Spectrum Disorders, 32, 13-23. 

https://www.sciencedirect.com/science/article/pii/S1750946716300927 


 

Post-traumatic stress disorder and autism

 

Sarr, R., Spain, D., Quinton, A., Happe, F., Brewin, C., Radcliffe, J., … Rumball, F. (2025). Differential diagnosis of autism, attachment disorders, complex post-traumatic stress disorder and emotionally unstable personality disorder: A Delphi survey. British Journal of Psychology, 116, 1-33.

https://bpspsychub.onlinelibrary.wiley.com/doi/10.1111/bjop.12731 

 

Rumball, F., Parker, R., Madigan, A. E., Happe, F. & Spain, D. (2024). Elucidating the presentation and identification of PTSD in autistic adults: A modified Delphi study. Advances in Autism, 10(3), 163-184.

https://www.emerald.com/insight/content/doi/10.1108/aia-08-2023-0053/full/html 

 

Rumball, F. & Spain, D. (2019). Post-traumatic stress disorder. In Chaplin, E., Spain, D. & McCarthy, J. (editors). Common mental health conditions in adults with autism spectrum disorders: Assessment and intervention. London: Jessica Kingsley Publishers.

https://us.jkp.com/products/a-clinicians-guide-to-mental-health-conditions-in-adults-with-autism-spectrum-disorders  


 

Obsessive compulsive disorder and autism

 

Cadman, T*., Spain, D*., Johnston, P., Russell, A., Mataix-Cols, D., Craig, M., … Murphy, D. (2015). Obsessive-compulsive disorder in adults with high-functioning autism spectrum disorder: What does self-report with the OCI-R Tell Us? Autism Research, 8, 477-485.

https://onlinelibrary.wiley.com/doi/10.1002/aur.1461 


 

Personality disorder and autism

 

Gillett, G., Leeves, L., Patel, A., Prisecaru, A., Spain, D*., & Happé, F*. (2023). The prevalence of autism spectrum disorder traits and diagnosis in adults and young people with personality disorders: A systematic review. Australian & New Zealand Journal of Psychiatry, 57, 181-196.

https://journals.sagepub.com/doi/full/10.1177/00048674221114603 


 

Paranoia and autism

 

Spain, D., Sin, J. & Freeman, D. (2016). Conceptualising paranoia in ASD: A systematic review and development of a theoretical framework. Research in Autism Spectrum Disorders, 25, 97-111.

https://www.sciencedirect.com/science/article/pii/S1750946716300137 


 

Psychosis and autism

 

Spain, D., Canning, A., Toogood, H. & Galanopoulos, A. https://www.autistica.org.uk/what-is-autism/psychosis-and-autism. Autistica. 


 

Risk, crisis and autism 

 

Gray, E., Rumball, Happé, F., Quinton, A. & Spain, D. (2025). Why does someone need to have a crisis before anyone will do anything?: Perspectives of Autism Intensive Support Team staff. Research in Autism, 123. 

https://www.sciencedirect.com/science/article/pii/S3050656525000173 

 

Allahdad, M., Gluyas, E., Spain, D., Blainey, S., Doswell, S., & Onyejiaka, A. (2024). Implementing ‘Transforming Care’–The first two years of a pilot service for autistic adults experiencing mental health crisis warranting psychiatric admission. Research in Developmental Disabilities, 147, 104700.

https://www.sciencedirect.com/science/article/abs/pii/S0891422224000325?via%3Dihub 

 

Autistica, autism community, Cassidy, S., Rodgers, J., Kyriakopoulos, M., Spain, D. et al. Supporting autistic children and young people through crisis – an Autistica evidence resource on suicide for crisis workers. Autistica.

https://www.autistica.org.uk/downloads/files/Crisis-resource-2020.pdf 


 

Adapting Psychological Therapy for Autistic Children and Young People

 

Pemovska, T., Loizou, S., Appleton, R., Spain, D., Stefanidou, T., Kular, A., ... & Johnson, S. (2024). Approaches to improving mental health care for autistic children and young people: A systematic review and meta-analysis. Psychological Medicine, 1-31.

https://www.cambridge.org/core/journals/psychological-medicine/article/approaches-to-improving-mental-health-care-for-autistic-children-and-young-people-a-systematic-review-and-metaanalysis/0B8C35C61254ADFFD8DBCFF7B8BF4BF7 


 

Adapting Psychological Therapy for Autistic Adults 

 

White, S., Golt, J., Musich, F. & Spain, D (2024). Psychotherapeutic Approaches for Autistic Adolescents and Adults. Volkmar, F., Reichow, B. & McPartland, J. (editors). Adolescents and adults with autism spectrum disorders. Springer. 

https://link.springer.com/chapter/10.1007/978-3-031-46463-8_17 

 

Loizou, S., Pemovska, T., Stefanidou, T., Foye, U., Cooper, R., Kular, A., ... & Johnson, S. (2024). Approaches to improving mental healthcare for autistic people: systematic review. BJPsych Open, 10(4), e128. 

 

https://www.cambridge.org/core/journals/bjpsych-open/article/approaches-to-improving-mental-healthcare-for-autistic-people-systematic-review/64C0BF732FAF7A80BDBD8341730EF7E2 

 

Mason, D., Stark, E., Musich, F. & Spain, D. (2022). Psychological therapy as an autistic person. In Spain, D., Musich, F. & White. S. (editors). Psychological therapies for adults with autism. Oxford University Press

https://oxfordjournals.org/book/37230/chapter-abstract/329246202?redirectedFrom=fulltext 

 

Spain, D., Musich, F. & White, S. (2022). Ensuring Accessible and Acceptable Service Delivery for Adults with Autism. In Spain, D., Musich, F. & White. S. (editors). Psychological therapies for adults with autism. Oxford University Press

https://academic.oup.com/book/37230/chapter-abstract/329248434?redirectedFrom=fulltext 

 

Spain, D., O'Neill, L., Harwood, L. & Chaplin, E. (2016). Psychological interventions for adults with ASD: Clinical approaches. Advances in Autism, 2, 24-30.

https://www.emerald.com/insight/content/doi/10.1108/aia-09-2015-0016/full/html 

 

Spain, D., Harwood, L. & O'Neill, L. (2015). Psychological interventions for adults with autism spectrum disorders: A review. Advances in Autism, 1, 79-86.

https://www.emerald.com/insight/content/doi/10.1108/aia-05-2015-0007/full/html 


 

Cognitive behaviour therapy (CBT) with autistic people

 

Spain, D., Milner, V., Mason, D., Iannelli, H., Attoe, C., Ampegama, R., ... & Marshall-Tate, K. (2023). Improving cognitive behaviour therapy for autistic individuals: A Delphi survey with practitioners. Journal of Rational-Emotive & Cognitive-Behavior Therapy, 41, 45-63.

https://link.springer.com/article/10.1007/s10942-022-00452-4 

 

Spain, D. & Happé, F. (2020). How to Optimise Cognitive Behaviour Therapy (CBT) for People with Autism Spectrum Disorders (ASD): A Delphi Study. Journal of Rational-Emotive & Cognitive-Behavior Therapy, 38, 184–208.

https://link.springer.com/article/10.1007/s10942-019-00335-1 

 

Spain, D. (2019). Cognitive behaviour therapy. In Chaplin, E., Spain, D. & McCarthy, J. (editors). Common mental health conditions in adults with autism spectrum disorders: Assessment and intervention. London: Jessica Kingsley Publishers.

https://us.jkp.com/products/a-clinicians-guide-to-mental-health-conditions-in-adults-with-autism-spectrum-disorders 

 

Spain, D. & Blainey, S. (2017). Enhancing self-esteem in adults with autism spectrum disorders: A pilot cognitive behaviour therapy (CBT) group intervention. Advances in Autism, 3, 66-75.

https://www.emerald.com/insight/content/doi/10.1108/aia-06-2016-0018/full/html 

 

Spain, D., Blainey, S. & Vaillancourt, K. (2017). Group cognitive behaviour therapy (CBT) for social interaction anxiety in adults with autism spectrum disorders (ASD). Research in Autism Spectrum Disorders, 41, 20-30.

https://www.sciencedirect.com/science/article/pii/S1750946717300855?via%3Dihub 

 

Spain, D., Sin, J., Harwood, L., Mendez, A. & Happé, F. (2017). Cognitive behaviour therapy for social anxiety in autism spectrum disorder: A systematic review. Advances in Autism, 3, 34-46.

https://www.emerald.com/insight/content/doi/10.1108/aia-07-2016-0020/full/html 

 

Spain, D., Sin, J., Chalder, T., Murphy, D. & Happé, F. (2015). Cognitive behaviour therapy for adults with autism spectrum disorders and psychiatric co-morbidity: A review. Research in Autism Spectrum Disorders, 9, 151-162.

https://www.sciencedirect.com/science/article/pii/S1750946714002608 


 

Eye movement desensitisation and reprocessing therapy (EMDR) with autistic people

 

van Diest, C., Leoni, M., Fisher, N., & Spain, D. (2022). Using EMDR With Autistic Clients: How Do Therapists Adapt?. Journal of EMDR Practice & Research, 16, 123-134.

https://spj.science.org/doi/10.1891/EMDR-2022-0014 


 

Fisher, N., Patel, H., van Diest, C., & Spain, D. (2022). Using eye movement desensitisation and reprocessing (EMDR) with autistic individuals: A qualitative interview study with EMDR therapists. Psychology and Psychotherapy: Theory, Research and Practice, 95, 1071-1089.

https://bpspsychub.onlinelibrary.wiley.com/doi/10.1111/papt.12419 

 

Fisher, N., van Diest, C., Leoni, M. & Spain, D. (2022). Using Eye Movement Desensitisation and Reprocessing (EMDR) with autistic individuals: A Delphi survey with EMDR therapists. Autism, 27, 43-53.

https://journals.sagepub.com/doi/10.1177/13623613221080254 


 

Compassion-focused therapy with autistic people

 

Mason, D., Acland, J., Stark, E., Happé, F., & Spain, D. (2023). Compassion-focused therapy with autistic adults. Frontiers in Psychology, 14, 1267968.

https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2023.1267968/full 

 

Acland, J. & Spain, D. (2022). Compassion-focused therapy. In Spain, D., Musich, F. & White. S. (editors). Psychological therapies for adults with autism. Oxford University Press

https://academic.oup.com/book/37230/chapter-abstract/329247814?redirectedFrom=fulltext 


 

Systemic (family) therapy with autistic people and their families

 

Spain, D., Sin, J., Paliokosta, E., Furuta, M., Prunty, J., Chalder, T., ... & Happé, F. (2017). Family therapy for autism spectrum disorders: Review. The Cochrane Library. 

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011894.pub2/full 

 

Spain, D., Sin, J., Paliokosta, E., Furuta, M., Prunty, J., Chalder, T., ... & Happé, F. (2016). Family therapy for autism spectrum disorders: Protocol. The Cochrane Library.

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011894.pub2/full 


 

Social skills interventions with autistic people

 

Spain, D. & Blainey, S. (2015). Group social skills interventions for adults with high-functioning autism spectrum disorders: A systematic review. Autism, 19, 874-886. 

https://journals.sagepub.com/doi/10.1177/1362361315587659 


 

The impact of the COVID-19 pandemic on autistic people, their families and autism services 

 

Evers, K., Gijbels, E., Maljaars, J., Rumball, F., Spain, D., Happé, F., & Noens, I. (2023). Mental health of autistic adults during the COVID-19 pandemic: The impact of perceived stress, intolerance of uncertainty, and coping style. Autism, 27, 832-847.

https://journals.sagepub.com/doi/10.1177/13623613221119749 

 

Spain, D., Stewart, G. R., Mason, D., Robinson, J., Capp, S., Gillan, N., ... & Happé, F. (2022). Autism diagnostic assessments with children, adolescents, and adults prior to and during the COVID-19 pandemic: a cross-sectional survey of professionals. Frontiers in Psychiatry, 13, 789449.

https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2022.789449/full 

 

Spain, D., Stewart, G., Mason, D., Milner, V., Fairhurst, B., Robinson, J., ... & Happe, F. (2022). Telehealth autism diagnostic assessments with children, young people, and adults: Qualitative interview study with England-wide multidisciplinary health professionals. JMIR Mental Health, 9, e37901.

https://mental.jmir.org/2022/7/e37901 

 

Maljaars, J., Gifjbels, E., Evers, K., Spain, D., Rumball, F., Happé, F. & Noens, I. (2022). Impact of the COVID-19 pandemic on daily life: diverse experiences for autistic adults. Journal of Autism & Developmental Disorders, 53, 319-331.

https://link.springer.com/article/10.1007/s10803-022-05437-x 

 

White, S., Stoppelbein, L., Scott, H., & Spain, D. (2021). It took a pandemic: Perspectives on impact, stress, and telehealth from caregivers of people with autism. Research in Developmental Disabilities, 113, 103938.

https://www.sciencedirect.com/science/article/pii/S0891422221000871?via%3Dihub 

 

Spain, D., Mason, D., Capp, S., Stoppelbein, L., White, S., & Happé, F. (2021). “This may be a really good opportunity to make the world a more autism friendly place”: Professionals’ perspectives on the effects of COVID-19 on autistic individuals. Research in Autism Spectrum Disorders, 83, 101747.

https://www.sciencedirect.com/science/article/pii/S1750946721000222?via%3Dihub 


 

Autism and Neuropsychology 

 

Johnston, K., Murray, K., Spain, D., Walker, I. & Russell, A. (2019). Executive function: cognition and behaviour in adults with autism spectrum disorders (ASD). Journal of Autism & Developmental Disorders, 49, 4181-4192.

https://link.springer.com/article/10.1007/s10803-019-04133-7 

 

Murray, K., Johnston, K., Cunnane, H., Kerr, C., Spain, D., Gillan, N., ... & Happé, F. (2017). A new test of advanced theory of mind: The “Strange Stories Film Task” captures social processing differences in adults with autism spectrum disorders. Autism Research, 10, 1120-1132.

https://onlinelibrary.wiley.com/doi/10.1002/aur.1744 

 

Wilson, C., Happé, F., Wheelwright, S. J., Ecker, C., Lombardo, M., Johnston, P., ... Murphy, D. (2014). The neuropsychology of male adults with high-functioning autism or Asperger syndrome. Autism Research, 7, 568-581.

https://onlinelibrary.wiley.com/doi/10.1002/aur.1394 


 

Autism and Camouflaging 

 

Lai, M., Lombardo, M., Chakrabarti, B., Ruigrok, A., Bullmore, E., Suckling, J., ... & MRC AIMS Consortium (2019). Neural self-representation in autistic women and association with ‘compensatory camouflaging’. Autism, 23, 1210-1223.

https://journals.sagepub.com/doi/10.1177/1362361318807159 

 

Lai, M., Lombardo, M., Ruigrok, A., Chakrabarti, B., Auyeung, B., Szatmari, P., … MRC AIMS Consortium, (2016).  Quantifying and exploring camouflaging in men and women with autism. Autism, 21, 690-702. 

https://journals.sagepub.com/doi/10.1177/1362361316671012 


 

Autism and Ageing

 

Yarar, E., Roestorf, A., Spain, D., Howlin, P., Bowler, D., Charlton, R., & Happé, F. (2022). Aging and autism: Do measures of autism symptoms, co‐occurring mental health conditions, or quality of life differ between younger and older autistic adults?. Autism Research, 15, 1482-1494.

https://onlinelibrary.wiley.com/doi/10.1002/aur.2780 


 

Autism and the Criminal Justice System 

 

Blackmore, C., Woodhouse, E., Gillan, N., Wilson, E., Ashwood, K., Stoencheva, V., ... & Daly, E. (2022). Adults with autism spectrum disorder and the criminal justice system: An investigation of prevalence of contact with the criminal justice system, risk factors and sex differences in a specialist assessment service. Autism, 26, 2098-2107.

https://journals.sagepub.com/doi/full/10.1177/13623613221081343 


 

Autism and Imaging 


 

Olafson, E., Bedford, S., Devenyi, G., Patel, R., Tullo, S., Park, M., ... & Chakravarty, M. (2021). Examining the Boundary Sharpness Coefficient as an Index of Cortical Microstructure in Autism Spectrum Disorder. Cerebral Cortex, 31, 3338-3352.

https://academic.oup.com/cercor/article/31/7/3338/6162915 

 

Mann, C., Schäfer, T., Bletsch, A., Gudbrandsen, M., Daly, E., Suckling, J., ... & Ecker, C. (2021). Examining volumetric gradients based on the frustum surface ratio in the brain in autism spectrum disorder. Human Brain Mapping, 42, 953-966.

https://onlinelibrary.wiley.com/doi/10.1002/hbm.25270 

 

Bletsch, A., Schafer, T., Mann, C., Andrews, D., Daly, E., Gudbrandsen, M., … & Ecker, C. (2020). Atypical measures of diffusion at the gray-white matter boundary in autism spectrum disorder in adulthood. Human Brain Mapping, 42, 467-484. 

https://onlinelibrary.wiley.com/doi/10.1002/hbm.25237 

 

Trakoshis, S., Martinez-Canada, P., Rocchi, F., Canella, C., You, W., Chakrabarti, B., ... & Lombardo, M. (2020). V. Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women. eLife. 

https://elifesciences.org/articles/55684 

Bedford, S., Park, M., Devenyi, G., Tullo, S., Germann, J., Patel, R., ... & Chakravarty, M. (2020). Large-scale analyses of the relationship between sex, age and intelligence quotient heterogeneity and cortical morphometry in autism spectrum disorder. Molecular Psychiatry, 25, 614-628.

https://www.nature.com/articles/s41380-019-0420-6 

 

Górriz, J., Ramirez, J., MRC AIMS Consortium & Suckling, J. (2019). On the computation of distribution-free performance bounds: Application to small sample sizes in neuroimaging. Pattern Recognition, 93, 1-13.

https://www.sciencedirect.com/science/article/abs/pii/S0031320319301402 

 

Guo, X., Simas, T., Lai, M., Lombardo, M., Chakrabarti, B., Ruigrok, A., ... & MRC AIMS Consortium. (2019). Enhancement of indirect functional connections with shortest path length in the adult autistic brain. Human Brain Mapping, 40, 5354-5369.

https://onlinelibrary.wiley.com/doi/10.1002/hbm.24777 

 

Horder, J., Andersson, M., Mendez Hernandez, A., Singh, N., Tangen, A., Lundberg, J., ... Borg, J. (2018). GABA receptor availability is not altered in adults with autism spectrum disorder or in mouse models. Science Translational Medicine, 10, eaam8434.

https://www.science.org/doi/10.1126/scitranslmed.aam8434 

 

Mann, C., Bletsch, A. Andrews, D., Daly, E., Murphy, C., MRC AIMS Consortium ... &. Ecker, C. (2018). The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder. Molecular Autism, 9, 49.

https://molecularautism.biomedcentral.com/articles/10.1186/s13229-018-0232-6 

 

Andrews, D., Avino, T., Gudbrandsen, M., Daly, E., Marquand, A., Murphy, C., … Ecker, C. (2017). In vivo evidence of reduced integrity of the gray-white matter boundary in autism spectrum disorder. Cerebral Cortex, 27, 877–887.

https://academic.oup.com/cercor/article/27/2/877/2834408# 

 

Ecker, C., Andrews, D., Gudbrandsen, C., Marquand, A., Ginestet, C., Daly, E., … MRC AIMS Consortium. (2017). Association between the probability of autism spectrum disorder and the normative sex-related phenotypic diversity in brain structure. JAMA Psychiatry, 74, 329-338.

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2601066 

 

Martinez-Murcia, F., Lai, M., Górriz, J., Ramírez, J., Young, A., Deoni, S., ... Williams, S. (2017). On the brain structure heterogeneity of autism: Parsing out acquisition site effects with significance-weighted principal component analysis. Human Brain Mapping, 38, 1208-1223.

https://onlinelibrary.wiley.com/doi/10.1002/hbm.23449 

 

Murphy, C., Christakou, A., Giampietro, V., Brammer, M., Daly, E. M., Ecker, C., ... Rubia, K. (2017). Abnormal functional activation and maturation of ventromedial prefrontal cortex and cerebellum during temporal discounting in autism spectrum disorder. Human Brain Mapping, 38, 5343-5355.

https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.23718 

 

Zeestraten, E., Gudbrandsen, M., Daly, E., de Schotten, M., Catani, M., Dell'Acqua, F., ... Murphy, D. M. (2017). Sex differences in frontal lobe connectivity in adults with autism spectrum conditions. Translational Psychiatry, 7, e1090.

https://www.nature.com/articles/tp20179 

 

Durieux, A., Horder, J., Hernandez, A., Egerton, A., Williams, S., Wilson, C., ... McAlonan, G. (2016). Cortical and subcortical glutathione levels in adults with autism spectrum disorder. Autism Research, 9, 429-435.

https://onlinelibrary.wiley.com/doi/full/10.1002/aur.1522 

 

Tropeano, M., Howley, D., Gazzellone, M., Wilson, C., Ahn, J., Stavropoulos, D., ... Murphy, D. (2016). Microduplications at the pseudoautosomal SHOX locus in autism spectrum disorders and related neurodevelopmental conditions. Journal of Medical Genetics, 53, 536-547.

https://jmg.bmj.com/content/53/8/536 

 

Catani, M., Dell'Acqua, F., Budisavljevic, S., Howells, H., Thiebaut De Schotten, M., Froudist-Walsh, S., ... Williams, S. (2016). Frontal networks in adults with autism spectrum disorder. Brain, 139, 616-630.

https://academic.oup.com/brain/article/139/2/616/1753965 

 

Ecker, C., Andrews, D., Dell’Acqua, F., Daly, E., Murphy, C., Catani, M., …MRC AIMS Consortium  (2016).  Relationship between cortical gyrification, white matter connectivity, and autism spectrum disorder. Cerebral Cortex, 26, 3297-3309.

https://academic.oup.com/cercor/article/26/7/3297/1746394 

 

Lombardo, M., Lai, M., Auyeung, B., Holt, R., Allison, C., Smith, P., … Baron-Cohen, S. (2016). Unsupervised data-driven stratification of mentalizing heterogeneity in autism. Scientific Reports, 6, 35333.

https://www.nature.com/articles/srep35333 

 

Balardin, J., Sato, J., Vieira, G., Feng, Y., Daly, E., Murphy, C., ... MRC AIMS Consortium (2015). Relationship between surface-based brain morphometric measures and intelligence in autism spectrum disorders: Influence of history of language delay. Autism Research, 8, 556-566.

https://docs.autismresearchcentre.com/papers/2015_Balardin_AutismResearch_Relationship-between-surface.pdf 

 

Balardin, J., Comfort, W., Daly, E., Murphy, C., Andrews, D., Murphy, D., … Sato, J.  (2015).  Decreased centrality of cortical volume covariance networks in autism spectrum disorders. Journal of Psychiatric Research, 69, 142-149.

https://www.sciencedirect.com/science/article/abs/pii/S0022395615002368 

 

Lai, M., Lombardo, M., Ecker, C., Chakrabarti, B., Suckling, J., Bullmore, E., … Baron-Cohen, S. (2015).  Neuroanatomy of individual differences in language in adult males with autism. Cerebral Cortex, 25, 3613-3628.

https://academic.oup.com/cercor/article/25/10/3613/389048?login=false 

 

Larson, F., Lai, M., Wagner, A., MRC AIMS Consortium, Baron-Cohen, S., & Holland, A., (2015). Testing the ‘Extreme Female Brain’ theory of psychosis in adults with autism spectrum disorder with or without co-morbid psychosis. PLoS ONE, 10: e0128102.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0128102 

 

Deoni, S., Zinkstok, J. R., Daly, E., Ecker, C., Williams, S. C. R., Murphy, D., Bailey, A., ... Williams, S. (2015). White-matter relaxation time and myelin water fraction differences in young adults with autism. Psychological Medicine, 45, 795-805.

https://www.cambridge.org/core/journals/psychological-medicine/article/abs/whitematter-relaxation-time-and-myelin-water-fraction-differences-in-young-adults-with-autism/358615BD9C7E494C84CE8F8EC4F2568D 

 

Daly, E., Ecker, C., Hallahan, B., Deeley, Q., Craig, M., Murphy, C., ... Murphy, D. (2014). Serotonin, the neural processing of response inhibition and restricted, stereotyped and repetitive behaviours in autism: A functional Magnetic Resonance Imaging study using acute tryptophan depletion. Brain, 137, 2600-2610.

https://academic.oup.com/brain/article/137/9/2600/2848190?login=false 

 

Chantiluke, K., Christakou, A., Murphy, C., Giampietro, V., Daly, E., Ecker, C., Brammer, M., … Rubia, K. (2014). Disorder-specific functional abnormalities during temporal discounting in youth with Attention Deficit Hyperactivity Disorder (ADHD), autism and comorbid ADHD and autism. Psychiatry Research: Neuroimaging, 223, 113-120.

https://www.sciencedirect.com/science/article/pii/S0925492714000936 

 

Murphy, C., Christakou, A., Daly, E., Ecker, C., Giampietro, V., Brammer, M., … MRC AIMS Consortium (2014).  Abnormal functional activation and maturation of fronto-striato-temporal and cerebellar regions during sustained attention in autism spectrum disorder. American Journal of Psychiatry, 171, 1107-1116.

https://psychiatryonline.org/doi/full/10.1176/appi.ajp.2014.12030352 

 

Suckling, J., Henty, J., Ecker, C., Deoni, S., Lombardo, M., Baron-Cohen, S., … MRC AIMS Consortium (2014). Are power calculations useful? A multicentre neuroimaging study. Human Brain Mapping, 35, 3569-3577.

https://onlinelibrary.wiley.com/doi/10.1002/hbm.22465 

 

Christakou, A., Murphy, C., Chantiluke, K., Cubillo, A., Smith, A., Giampietro, V., … Rubia, K.  (2013). Disorder-specific functional abnormalities during sustained attention in youth with Attention Deficit Hyperactivity Disorder (ADHD) and with autism. Molecular Psychiatry, 18, 236-244.

https://www.nature.com/articles/mp2011185 

 

Ecker, C., Ginestet, C., Feng, Y., Johnston, P., Lombardo, M., Lai, M., … MRC AIMS Consortium (2013). Brain surface anatomy in adults with autism: the relationship between surface area, cortical thickness and autistic symptoms. JAMA Psychiatry, 70, 59-70.

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/1393585 

 

Ecker, C., Ronan, L., Feng, Y., Daly, E., Murphy, C., Ginestet, C., … Murphy, D. (2013). Intrinsic gray-matter connectivity of the brain in adults with autism spectrum disorder. Proceedings of the National Academy of Sciences, 110, 13222–13227.

https://www.pnas.org/doi/full/10.1073/pnas.1221880110 

 

Lai, M., Lombardo, M., Suckling, J., Ruigrok, A., Chakrabarti, B., Ecker, C., … Baron-Cohen, S. (2013). Biological sex affects the neurobiology of autism. Brain, 136, 2799-2815.

https://academic.oup.com/brain/article/136/9/2799/292799?login=false 

 

Sato, J., Hoexter, M., Oliveira Jr, P., Brammer, M., MRC AIMS Consortium, Murphy, D. & Ecker, C.  (2013). Inter-regional cortical thickness correlations are associated with autistic symptoms: A machine-learning approach. Journal of Psychiatric Research, 47, 453-459.

https://www.sciencedirect.com/science/article/abs/pii/S0022395612003597 

 

Ecker, C., Suckling, J., Deoni, S., Lombardo, M.V., Bullmore, E., Baron-Cohen, S., … the MRC AIMS Consortium (2012).  Brain anatomy and its relationship to behavior in adults with autism spectrum disorder: a multicenter magnetic resonance imaging study. Archives of General Psychiatry, 69, 195-209.

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/1107445 

 

Lai, M., Lombardo, M., Chakrabarti, B., Ecker, C., Sadek, S., Wheelwright, S., … Baron-Cohen, S. (2012). Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults. Neuroimage, 61, 1347-1354.

https://www.sciencedirect.com/science/article/pii/S1053811912002911 

 

Langen, M.,  Leemans,  A.,  Johnston,  P.,  Ecker,  C.,  Daly,  E.,  Murphy,  C.,  … Murphy,  D.  (2012).  Fronto-striatal circuitry and inhibitory control in autism:  Findings from diffusion tensor imaging tractography. Cortex, 48, 183-193.

https://www.sciencedirect.com/science/article/abs/pii/S0010945211001626 

 

Lombardo, M., Chakrabarti, B., Lai, M., MRC AIMS Consortium & Baron-Cohen, S. (2012). Self-referential and social cognition in a case of autism and agenesis of the corpus callosum. Molecular Autism, 3, 14.

https://molecularautism.biomedcentral.com/articles/10.1186/2040-2392-3-14 

 

Lombardo, M., Chakrabarti, B., Bullmore, E., MRC AIMS Consortium & Baron-Cohen, S. (2011). Specialization of right temporo-parietal junction for mentalizing and its relation to social impairments in autism. Neuroimage, 56, 1832-1838.

https://www.sciencedirect.com/science/article/abs/pii/S1053811911002230?via%3Dihub 

 

Ecker, C., Rocha-Rego, V., Johnston, P., Mourao-Miranda, J., Marquand, A., Daly, E., … MRC AIMS Consortium (2010). Investigating the predictive value of whole-brain structural MR scans in autism: A pattern classification approach. Neuroimage, 49, 44-56.

https://www.sciencedirect.com/science/article/abs/pii/S1053811909009045?via%3Dihub 

 

Lai, M., Lombardo, M., Chakrabarti, B., Sadek, S., Pasco, G., Wheelwright, S., … Suckling, J. (2010). A shift to randomness of brain oscillations in people with autism. Biological Psychiatry, 68, 1092-1099.

https://www.biologicalpsychiatryjournal.com/article/S0006-3223(10)00708-0/abstract 

 

Lombardo, M., Chakrabarti, B., Bullmore, E., Sadek, S., Pasco, G., Wheelwright, S., … Baron-Cohen, S. (2010).  Atypical neural self-representation in autism. Brain, 133, 611-624.

https://academic.oup.com/brain/article-abstract/133/2/611/287808?redirectedFrom=fulltext 

 

Lombardo, M., Chakrabarti, B., Bullmore, E., Wheelwright, S., Sadek, S., Suckling, J., … Baron-Cohen, S. (2010). Shared neural circuits for mentalizing about the self and others. Journal of Cognitive Neuroscience, 277, 1623-1635.

https://direct.mit.edu/jocn/article/22/7/1623/4904/Shared-Neural-Circuits-for-Mentalizing-about-the 

Adult ADHD

Maltezos, S., Horder, J., Coghlan, S., Skirrow, C., O'Gorman, R., Lavender, T., ... Murphy, D. (2014). Glutamate/glutamine and neuronal integrity in adults with ADHD: A proton MRS study. Translational Psychiatry, 4, e373.

https://www.nature.com/articles/tp201411 

 

Bramham, J., Young, S., Bickerdike, A., Spain, D., McCartan, D. & Xenitidis, K. (2009). Evaluation of group cognitive behavioral therapy for adults with ADHD. Journal of Attention Disorders, 12, 434-441.

https://journals.sagepub.com/doi/10.1177/1087054708314596

Alexithymia

Fairhurst, B. (2017). Can’t talk about it, won’t talk about it : how do alexithymia and experiential avoidance relate to men’s experience of psychological distress? Doctoral thesis. University of Surrey. 

https://openresearch.surrey.ac.uk/esploro/outputs/doctoral/Cant-talk-about-it-wont-talk/99515120702346#details 

Post-Traumatic Stress Disorder

Sarr, R., Quinton, A., Spain, D., & Rumball, F. (2024). A Systematic Review of the Assessment of ICD‐11 Complex Post‐Traumatic Stress Disorder (CPTSD) in Young People and Adults. Clinical Psychology & Psychotherapy, 31(3), e3012.

https://onlinelibrary.wiley.com/doi/full/10.1002/cpp.3012

Perinatal Mental Health

Furuta, M., Horsch, A., Ng, E., Bick, D., Spain, D. & Sin, J. (2018). Psychological therapies for treating post-traumatic stress disorder symptoms in women following childbirth: A systematic review and meta-analysis. Frontiers in Psychiatry, 5,591. 

https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2018.00591/full 

 

Furuta, M., Spain, D., Bick, D., Ng, E. S. W. & Sin, J. (2016). Effectiveness of trauma-focused psychological therapies compared to usual postnatal care for treating post-traumatic stress symptoms in women following traumatic birth: A systematic review protocol. BMJ Open, 6, e013697. 

https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2018.00591/full

Psychosis

Psychological therapy for Post-traumatic stress disorder in people who have psychosis

 

Sin, J., Spain, D., Murrells, T., Norman, I. & Furuta, M. (2017). Psychological interventions for post-traumatic stress disorder (PTSD) in people with severe mental illness: Review. The Cochrane Library. 

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011464.pub2/full 

 

Sin, J. & Spain, D. (2017). Psychological interventions for trauma in individuals who have psychosis: A systematic review and meta-analysis. Psychosis, 9, 67-81.

https://www.tandfonline.com/doi/full/10.1080/17522439.2016.1167946 

 

Sin, J., Spain, D., Murrells, T, Norman, I. & Furuta, M. (2015). Psychological interventions for post-traumatic stress disorder (PTSD) in people with severe mental illness: Protocol. The Cochrane Library.

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011464.pub2/full 


 

Understanding the mental health of families of people who have psychosis

 

Sin, J., Murrells, T., Spain, D., Norman, I. & Henderson, C. (2016). Wellbeing, mental health knowledge and caregiving experiences of siblings of people with psychosis, compared to their peers and parents: An exploratory study. Social Psychiatry & Psychiatric Epidemiology, 51, 1247-1255.

https://link.springer.com/article/10.1007/s00127-016-1222-7 

 

Sin, J., Spain, D., Jordan, C. & Griffiths, C. (2014). Siblings of individuals with severe mental illness. Journal of Mental Health Training, Education & Practice, 9, 215-221.

https://www.emerald.com/insight/content/doi/10.1108/jmhtep-04-2014-0006/full/html 

Psychological interventions and therapy for families of people who have psychosis

Sin, J., Henderson, C., Spain, D., Cornelius, V., Chen, T. & Gillard, S. (2018). eHealth interventions for family carers of people with long term illness: A promising approach? Clinical Psychology Review, 60, 109-125.

https://www.sciencedirect.com/science/article/pii/S0272735817300818?via%3Dihub 

 

Sin, J., Henderson, C., Spain, D., Gamble, C. & Norman, I. (2017). What factors influence successful recruitment of siblings of individuals with first episode psychosis to e‐health interventions? A qualitative study. Health Expectations, 20, 696-704.

https://onlinelibrary.wiley.com/doi/10.1111/hex.12508 
 

Sin, J., Gillard, S., Spain, D., Cornelius, V., Chen, T. & Henderson, C. (2017). Effectiveness of psychoeducational interventions for family carers of people with psychosis: A systematic review and meta-analysis. Clinical Psychology Review, 56, 13-24.

https://www.sciencedirect.com/science/article/pii/S0272735816303452 

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